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#somatic hybridization

11 public questions tagged with this topic.

Somatic hybridization can transfer:

Somatic hybridization can transfer extensive genetic material ranging from blocks of linked genes to entire chromosomes or whole genomes, contrasting with single gene transformation using plasmid vectors. When two protoplasts fuse, initial heterokaryon contains cytoplasm of both parents and nuclei that may fuse producing allotetraploid somatic hybrid carrying full complement of chromosomes from both species, allowing introgression of polygenic quantitative trait loci QTL controlled by multiple genes interacting for disease resistance, abiotic stress tolerance, quality attributes that cannot be transferred via single gene approach. Through asymmetric fusion where donor protoplasts irradiated with gamma rays fragment chromosomes before fusion, partial genome transfer achieved moving chromosome segments or single added chromosomes into recipient background, verifiable by genomic in situ hybridization GISH. This permits wide hybridization circumventing sexual incompatibility barriers pre zygotic and post zygotic including endosperm abortion. Iconic examples include transfer of late blight resistance gene cluster from wild Solanum brevidens to cultivated potato conferring durable resistance dependent on multiple R genes clustered in genomic block, demonstrating somatic hybridization power for moving complex agronomic traits impossible by conventional crossing.

Ref: Helgeson 1979 potato somatic hybrid; Bhat & Bhat 2011 gene blocks transfer.

Somatic hybridization involves fusion of:

Somatic hybridization involves fusion of protoplasts isolated from somatic vegetative tissues of different species cultivars or genera, bypassing sexual incompatibility barriers that prevent conventional crossing due to pre zygotic pollen stigma incongruence or post zygotic endosperm abortion. Protoplasts are obtained by enzymatic digestion of cell walls using cellulase Onozuka R-10 and macerozyme releasing naked cells bounded solely by plasma membrane maintaining totipotency to regenerate wall and divide. Mixed protoplast populations labeled with different fluorescent markers or selectable complementation traits are induced to fuse using polyethylene glycol PEG with calcium at high pH causing membrane dehydration and coalescence or by electrofusion using alternating current for alignment and direct current pulses for reversible membrane breakdown forming heterokaryons containing mixed cytoplasms and nuclei. Fusion product nuclear fusion may produce symmetric somatic hybrid allotetraploid containing both parental chromosome sets or after chromosome elimination asymmetric hybrids carrying partial genomes. This technique enabled transfer of polygenic traits disease resistance abiotic tolerance cytoplasmic male sterility from wild relatives to crops, exemplified by pomato potato plus tomato fusion and citrus somatic hybrids for rootstock improvement.

Ref: Gleba & Sytnik 1984 somatic hybridization; Evans et al., Handbook Plant Cell Culture.