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#smooth ER

4 public questions tagged with this topic.

BOTANY

Which of the following is NOT a function of the smooth endoplasmic reticulum?

Protein synthesis occurs in the rough ER, not the smooth ER, which is involved in lipid metabolism and detoxification. This follows from latest NCERT 2026-27 principle explaining the concept clearly for NEET students in simple steps as per rationalized syllabus.

Ref: NCERT Biology Textbook - Latest Edition for Academic Session 2026-27 (Botany section, Rationalized Textbook for Class XI and XII), Chapter: Biology - Botany portion (Latest NCERT Textbooks for Academic Session 2026-27 -

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Cell Organelles

Which enzyme is found inside the smooth ER for glucose metabolism?

Maintaining blood glucose between meals requires hepatic glucose output via glycogen breakdown and gluconeogenesis. Both pathways converge on glucose-six-phosphate cytosolic that cannot exit cell due to charge; final dephosphorylation occurs inside endoplasmic reticulum lumen by glucose-six-phosphatase complex composed of transporter T1 importing G6P, catalytic subunit facing lumen hydrolyzing to glucose and Pi, transporters T2 and T3 exporting Pi and glucose. Active site luminal protects against futile cycling by cytosolic hexokinase. Enzyme enriched in smooth ER of hepatocytes and kidney cor

Ref: Foster J Biol Chem; glucose-6-phosphatase ER lumen T1 translocase gluconeogenesis von Gierke.

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Cell Organelles

The smooth ER plays a crucial role in:

Smooth ER forms anastomosing tubules without ribosomes enriched in enzymes for lipid and xenobiotic metabolism. In hepatocytes it contains cytochrome P450 monooxygenases, NADPH-cytochrome P450 reductase, UDP-glucuronosyltransferases and sulfotransferases that hydroxylate, reduce and conjugate lipophilic drugs, environmental pollutants and endogenous steroids to make them water soluble for biliary or renal excretion. Chronic exposure to phenobarbital induces proliferation of smooth ER increasing detoxification capacity, observed by proliferation of membranes in electron micrographs. Additionall

Ref: Alberts Ch 12; smooth ER CYP450 detoxification, lipid synthesis, SERCA calcium storage, SAR.

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