Inhibition of adenylyl cyclase is mediated by
Adenylyl cyclase catalyzes the conversion of ATP to the second messenger cyclic AMP. The enzyme is stimulated by GTP-bound Gαs and inhibited by GTP-bound Gαi. The resulting changes in cAMP concentration regulate protein kinase A and cyclic-nucleotide-gated channels, linking G-protein-coupled receptors to diverse physiological responses. Careful
Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)