Signal amplification in GPCR pathway occurs via
Signal amplification occurs when a single activated receptor molecule catalyzes the activation of many downstream molecules, each of which can in turn activate still more targets. Phosphorylation cascades and second-messenger systems are classic examples. Amplification enables a small number of ligand–receptor complexes to generate a large cellular response while preserving specificity through spatial and molecular constraints.
Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)
