Which of the following ATP-powered pumps is responsible for maintaining resting membrane potential?
Resting membrane potential stability essential for excitability maintained by differential permeability and active ion distribution. Key player is Na+/K+ ATPase, P-type ion pump encoded by ATP1A genes for alpha isoforms, ATP1B for beta, FXYD for gamma regulatory. Catalytic alpha subunit roughly 112 kDa with ten membrane spans contains nucleotide N domain binding ATP, phosphorylation P domain with conserved DKTGTLT aspartate that forms phosphoenzyme intermediate, actuator A domain and transmembrane ion binding pocket coordinating ions with carbonyl oxygens. Cycle Post-Albers: E1 high Na affinit
Ref: Skou and Glynn, P-Type ATPases Review, Na+/K+ ATPase Role in Resting Membrane Potential Maintenance.