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#recessive traits

4 public questions tagged with this topic.

X-linked recessive traits are never transmitted from

Father transmits Y chromosome to sons and X chromosome to daughters during fertilization. Since X-linked genes reside on X chromosome, father cannot transmit X-linked allele to son who receives paternal Y instead of paternal X. Sons obtain their single X exclusively from mother. Consequently father-to-son transmission in pedigree excludes X-linked inheritance and suggests autosomal or Y-linked pattern. In X-linked recessive pedigrees, affected males must receive mutant X from carrier mother, and affected fathers pass mutant X to all daughters, making them obligate carriers, never to sons.

Ref: Hartl & Ruvolo, Genetics, 6th ed., Chapter 4: Sex Linkage and Father to Son Transmission Rule

X-linked recessive traits are more commonly seen in

X-linked recessive alleles reside physically on X chromosome. Males are hemizygous with XY constitution, possessing single X copy, so any recessive allele on that X fully expresses without masking. Females possess two X chromosomes, requiring two copies to show affected phenotype, usually remaining shielded as heterozygous carriers with normal phenotype. Therefore trait appears predominantly in males across pedigree, while females serve as transmitters. This explains male bias in hemophilia, Duchenne muscular dystrophy, and red-green color blindness pedigrees where affected males connect through unaffected carrier females.

Ref: Griffiths et al., Introduction to Genetic Analysis, 12th ed., Chapter 2: X-linked Recessive Male Predominance