Which receptor recognizes peroxisomal proteins containing a PTS1 signal?
Peroxisomal biogenesis uses two soluble receptors distinguishing two signals. Pex5 70 kDa primary receptor PTS1 pathway handling bulk matrix proteins catalase ACOX1 DBP. Structurally N-terminal half intrinsically disordered contains multiple WXXXF motifs interacting peroxisomal membrane docking protein Pex14 N-terminal domain plus cysteine ubiquitination sites recycling amphipathic helices; C-terminal seven tetratricopeptide repeats TPR 34 aa folding two half-rings superhelical clamp central cavity accommodating C-terminal tripeptide Ser-Lys-Leu water-mediated hydrogen bonds explaining toleran
Ref: Smith & Subramani, Annu Rev Cell Dev Biol 2019: Pex5 receptor recognizes PTS1 signal.