Protease inhibitors are added to prevent:
Innate immunity balances protease mediated tissue remodeling with protective antiproteases preventing autodamage. Neutrophils recruited to injury sites degranulate releasing azurophilic granules containing serine protease neutrophil elastase capable of degrading elastin collagen, cathepsin G, proteinase 3, and specific granules releasing matrix metalloproteases MMP8 collagenase and MMP9 gelatinase facilitating migration through basement membrane. Uncontrolled release would destroy cartilage and lung parenchyma causing emphysema in alpha-1 antitrypsin deficiency. Plasma contains defensive inhib
Ref: Lodish Molecular Cell Biology serpin α1 antitrypsin α2 macroglobulin; Alberts MBoC protease inhibitors serum protection lysis cocktail.