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#prophase I

18 public questions tagged with this topic.

Which of the following occurs during zygotene of prophase I?

During zygotene, homologous chromosomes start pairing, a process called synapsis, forming bivalents. This follows from NCERT principle where relation explains outcome clearly for students.

Ref: NCERT Biology Textbook for Class XI and XII (Botany section), Chapter: Biology - Botany portion covering relevant concept, Topic: Plant structure, physiology and applications.

Which substage of prophase I is characterized by crossing over?

Pachytene represents longest stable meiotic prophase stage where fully synapsed bivalents thicken and crossing over implemented. Molecular hallmark is homology-directed repair of programmed double-strand breaks introduced by Spo11 topoisomerase-like transesterase in leptotene that generates 3 prime single-strand overhangs via MRE11-mediated resection. Overhangs invade homologous duplex mediated by meiosis-specific recombinases DMC1 and RAD51, forming D-loop intermediates. Decision between non-crossover and crossover fate controlled by ZMM proteins MSH4-MSH5 heterodimer stabilizing joint molecu

Ref: Hunter, Cold Spring Harb Perspect Biol 2015, Meiotic Recombination in Pachytene. Alberts 7th ed., Chapter 21.

Which phase of meiosis involves the formation of the synaptonemal complex?

Prophase of meiosis I is extended into five substages to accomplish pairing, synapsis, and recombination unique to germ cells. Leptotene initiates with chromosome condensation into thin threads and formation of axial elements along each chromatid containing cohesin Rec8 and HORMA proteins. Zygotene marks onset of homologous pairing facilitated by telomere bouquet clustering at nuclear envelope driven by cytoskeletal forces and homology search mediated by DMC1 recombinase. Synaptonemal complex assembly begins in zygotene: lateral elements SYCP2 and SYCP3 polymerize along axes, transverse filame

Ref: Page & Hawley, Annu Rev Cell Dev Biol 2004, Meiotic Synapsis. Alberts 7th ed., Chapter 21, Meiosis I Prophase.