Riboswitch regulation occurs at level of
Riboswitches are cis-acting structured RNA elements located predominantly in 5' untranslated regions of bacterial mRNAs that directly sense metabolites without protein factors. Ligand binding to conserved aptamer induces conformational rearrangement of downstream expression platform, modulating gene expression response. Two widespread mechanisms exist: transcription attenuation through stabilization of intrinsic Rho-independent terminator hairpin versus antiterminator formation, and translational repression by sequestering Shine-Dalgarno sequence within stem-loop. This economical RNA-only feed
Ref: NCBI Bookshelf, Biochemistry: Regulatory RNAs – Riboswitch Mechanism, Transcriptional and Translational Control