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A peptide bond forms between the carboxyl group of one amino acid and the amino group of another during protein synthesis.
Ref: NCERT Class 11 Biology Chapter 9: Biomolecules Chemical Analysis and Biomolecules - Amino Acids Lipids
Completion of protein synthesis releases nascent chain through polypeptide exit tunnel traversing core of large subunit from peptidyl transferase center to solvent-exposed surface, spanning about 100 angstroms. Tunnel walls built from segments of 23S or 28S rRNA and constriction proteins L4, L22, L23 regulate folding, permit alpha-helix formation inside, and provide binding platform for chaperones like trigger factor, signal recognition particle SRP, and modification enzymes NAC and methionine aminopeptidase that act co-translationally to target or process emerging polypeptide for secretion an
Ref: Alberts et al., Molecular Biology of the Cell, 7th ed., Chapter 7, Nascent polypeptide exit tunnel in large subunit
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