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#phosphodiesterase

3 public questions tagged with this topic.

Dictyostelium

cAMP degradation mediated by:

Temporal shaping of extracellular cAMP waves depends on regulated degradation preventing uniform saturation. Secreted phosphodiesterase PdsA hydrolyzes cAMP to AMP in extracellular medium, creating troughs between pulses that allow receptor resensitization and directional sensing. PdsA is expressed during aggregation from cAMP-inducible promoter, membrane-associated, and inhibited by specific inhibitor PdiA. RegA degrades intracellular cAMP, ACA synthesizes cAMP, PiaA couples TOR complex 2 to ACA activation. Without PdsA, cAMP accumulates uniformly, abolishing gradient, cells fail to aggregate

Ref: Journal of Cell Biology, PdsA extracellular phosphodiesterase - cAMP wave shaping and aggregation chemotaxis.

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Cell Signaling GPCR Pathways - I

Phosphodiesterase terminates GPCR signaling by converting

Cyclic-nucleotide phosphodiesterases hydrolyze cAMP or cGMP to the corresponding inactive 5'-monophosphates, thereby terminating the second-messenger signal. Regulation of phosphodiesterase activity provides an important mechanism for controlling the duration and amplitude of cyclic-nucleotide signaling in cells. These enzymes are important pharmacological targets for modulating cyclic nucleotide levels. Careful

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Signaling GPCR Pathways - I

Phosphodiesterase terminates signaling by

Cyclic-nucleotide phosphodiesterases hydrolyze cAMP or cGMP to the corresponding inactive 5'-monophosphates, thereby terminating the second-messenger signal. Regulation of phosphodiesterase activity provides an important mechanism for controlling the duration and amplitude of cyclic-nucleotide signaling in cells. These enzymes are important pharmacological targets for modulating cyclic nucleotide levels. Careful

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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