Skip to content
Login Register

#ovary development

2 public questions tagged with this topic.

sex determination-ll

Which gene stimulates Disheveled protein to promote ovary development?

R-spondin1 encoded by Rspo1 is secreted potentiator of Wnt signaling indispensable for ovary determination. It binds Lgr receptors and simultaneously inhibits E3 ligases Znrf3/Rnf43, stabilizing Frizzled surface expression and sensitizing pre-granulosa cells to Wnt4 ligand. Enhanced signaling activates Disheveled, suppresses Gsk3β, causing β-catenin stabilization and nuclear translocation to drive female program. Human RSPO1 recessive mutations cause complete female-to-male sex reversal with XX testes, palmoplantar hyperkeratosis, while knockout mice show masculinized gonads lacking Wnt4 activation, demonstrating its role as organizer of ovarian pathway.

Ref: Nature Reviews Genetics, 2017, Rspo1-Wnt4-β-catenin axis in mammalian ovary development.

View Details
plant Development - 1

Fruit formation involves development of:

Fruit formation predominantly involves development of ovary after successful fertilization triggered by hormonal signals including auxin, gibberellin, and cytokinin produced by developing seeds preventing abscission zone activation and stimulating cell division and expansion programs. Ovary wall differentiates into pericarp comprising exocarp, mesocarp, and endocarp whose texture, lignification, and sugar content define fleshy drupes and berries versus dry dehiscent or indehiscent pods. Accessory tissues like receptacle may contribute forming pome or aggregate fruits. Maturation ensures coordinated seed protection and effective dispersal via animal ingestion or wind currents.

Ref: Gillaspy et al., Plant Cell 1993: fruit formation involves ovary development after fertilization driven by auxin/GA signals.

View Details