The outer mitochondrial membrane contains:
Outer membrane of mitochondrion is symmetric phospholipid bilayer containing cholesterol and porin channels that confer permeability to small solutes under five kilodaltons, distinguishing it from highly selective inner membrane bearing electron transport chain. Integral protein voltage-dependent anion channel VDAC, also called porin, forms nineteen-stranded beta-barrel with N-terminal alpha helix gating, isoforms VDAC1 most abundant, VDAC2, VDAC3 regulate metabolite exchange ADP ATP across intermembrane space, calcium transfer at mitochondria ER associated membranes interacting with IP3R via
Ref: Shoshan-Barmatz Cell Death Dis; VDAC outer membrane porin metabolite gatekeeper apoptosis regulation.
