Inflammasomes formed by some NLRs activate
Cytosolic NOD-like receptors detect microbial products or danger signals and can assemble multiprotein inflammasomes that activate caspase-1. Caspase-1 processes the pro-inflammatory cytokines IL-1β and IL-18 and also cleaves gasdermin D to induce pyroptosis. Inflammasome activation therefore links intracellular sensing to both cytokine release and inflammatory cell death. Careful
Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)