What happens if dynein function is disrupted?
Axonal and cytoplasmic retrograde transport essential for neuronal survival autophagic clearance and degradation pathways relies on cytoplasmic dynein 1 delivering cargo to perinuclear lysosomes and Golgi apparatus clustering center. Cargo including late endosomes autophagosomes signaling endosomes carrying neurotrophins TrkB and NGF Golgi fragments and aggregated misfolded proteins move from periphery toward centrosome where microtubule minus ends anchor near nucleus. Mechanistically dynein adaptors such as BicD2 Hook1 Rab11 FIP3 recruit cargos link to dynactin Arp1 filament increasing run le
Ref: Reck-Peterson et al., Nat Rev Mol Cell Biol 2018 – Dynein disruption impairs transport toward Golgi phenotype.