Which factor regulates the exit of cells from mitosis?
Exit from mitosis, defined transition from high CDK1 activity driving chromosome condensation and spindle assembly to low CDK state permitting G1 growth, is regulated primarily by anaphase-promoting complex/cyclosome APC/C ubiquitin ligase. After anaphase onset mediated by APC/C-Cdc20 degradation of securin and cyclin B, second wave of APC/C activity associated with coactivator Cdh1 becomes dominant as CDK1 inactivation allows Cdc14 and PP2A phosphatases to dephosphorylate Cdh1 permitting its binding. APC/C-Cdh1 polyubiquitinates remaining mitotic cyclin B, Polo-like kinase, Aurora kinases A a
Ref: Sullivan & Morgan, Nature Rev Mol Cell Biol 2007, Mitotic Exit Control. Alberts 7th ed., Chapter 17.