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#liver

8 public questions tagged with this topic.

Membrane Transportation

Which ABC transporter is found in the liver and is responsible for phosphatidylcholine transport?

Hepatic bile secretion relies on coordinated action of several canalicular ABC transporters in hepatocytes. ABCB11 BSEP exports bile acids, ABCG5/ABCG8 heterodimer exports cholesterol, and ABCB4 previously called MDR2 in mice and MDR3 in humans is dedicated to phosphatidylcholine. ABCB4 acts as ATP-dependent floppase moving phosphatidylcholine from inner cytoplasmic leaflet to outer exoplasmic leaflet of canalicular membrane where bile salt micelles extract it into biliary space forming mixed micelles. This phospholipid shield protects cholangiocyte membranes from detergent attack by hydrophob

Ref: Oude Elferink & Paulusma, Pflugers Arch 2007, ABCB4 bile phospholipid secretion.

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A Cell Signaling

Correct order of epinephrine signaling in liver is:

G protein → AC → cAMP → PKA, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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