Which enzyme is responsible for maintaining lipid asymmetry by moving phospholipids to the inner leaflet?
Enzymatic control of transbilayer phospholipid distribution involves three distinct activities defined directionally. Flippase originally term for inward moving ATP dependent P4-ATPases ATP8A1 present in liver canaliculi ATP8B1 deficient in familial intrahepatic cholestasis, ATP11C required lymphocyte development, translocate aminophospholipids phosphatidylserine and phosphatidylethanolamine from exoplasmic to cytosolic leaflet maintaining negative inner surface important for vesicle formation and apoptosis prevention. Floppase ABC transporters ABCB1 multidrug resistance P-glycoprotein ABCB4 p
Ref: Pomorski et al., Lipid Transport by P4-ATPase Flippases, J Lipid Res Review.