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#ligand-receptor interaction

2 public questions tagged with this topic.

Cell Signaling Fundamental Principles

Higher affinity corresponds to

lower Kd, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Signaling Fundamental Principles

Affinity of ligand–receptor interaction in Scatchard plot is obtained from

Affinity of a ligand–receptor interaction is quantified by the dissociation constant Kd. In a Scatchard plot the bound/free ligand ratio is graphed against bound ligand concentration. The resulting straight line has a slope equal to –1/Kd. Therefore the numerical value of the slope directly reports affinity: the steeper the negative slope, the higher the affinity. This linearization remains a classical method for extracting both affinity and receptor density from equilibrium binding data. Careful

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details