#laminin

Animal Tissue Culture 1

Laminin in serum mainly functions as:

Laminin represents major non-collagenous component of basement membrane thin sheet of specialized extracellular matrix ten to one hundred nanometers thick underlying epithelia, surrounding muscle fibers, Schwann cells, essential for tissue integrity and polarity. Heterotrimeric glycoprotein about eight hundred fifty kilodalton composed of alpha, beta, gamma chains encoded by different genes LAMA LAMB LAMC, assembled in endoplasmic reticulum via coiled coil heptad repeat forming long arm approximately eighty nanometers and three short arms each thirty nanometers forming cross-shaped molecule ob

Ref: Yurchenco & Patton 1994 laminin heterotrimer basement membrane LG domains; Alberts MBoC integrin α6β1 α6β4 attachment survival.

View Details

Cell Communication and ECM

Laminin is best described as

Heterotrimeric protein, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details

Cell Communication and ECM

Which ECM component links laminin to collagen IV?

Nidogen (entactin), is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details

Cell Communication and ECM

Which ECM protein forms a sheet-like network?

Collagen IV, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details