The Na+/K+ ATPase pump transports:
Sodium-potassium pump is archetypal P-type ATPase maintaining electrochemical gradients vital for volume control and excitability. Each cycle hydrolyzes one ATP to ADP and phosphate, driving conformational shift from E1 high Na+ affinity inward to E2 low affinity outward via phosphorylated Asp369 intermediate. In E1 facing cytosol, cavity binds three sodium ions, triggering autophosphorylation. Transition to E2-P exposes cavity extracellularly where Na+ affinity drops, sodium released and potassium sites exposed. Two extracellular potassium ions bind with high affinity in E2-P, inducing dephos
Ref: Skou & Esmann, Journal of Bioenergetics 1992: Na+,K+-ATPase Stoichiometry – 3 Na+ out, 2 K+ in.