Intracellular receptors often act as
Many intracellular receptors for hydrophobic ligands belong to the nuclear-receptor superfamily. Upon ligand binding they undergo conformational changes that enable DNA binding and recruitment of co-activators or co-repressors, thereby regulating transcription of specific target genes. This direct genomic mode of action accounts for the relatively slow but long-lasting effects of steroid and thyroid hormones.
Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)
