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#immune activation

2 public questions tagged with this topic.

Immunology

Inflammasomes formed by some NLRs activate

Cytosolic NOD-like receptors detect microbial products or danger signals and can assemble multiprotein inflammasomes that activate caspase-1. Caspase-1 processes the pro-inflammatory cytokines IL-1β and IL-18 and also cleaves gasdermin D to induce pyroptosis. Inflammasome activation therefore links intracellular sensing to both cytokine release and inflammatory cell death. Careful

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Immunology

Cathelicidin (LL-37) becomes active after

Antimicrobial peptides such as defensins and cathelicidins are cationic molecules that disrupt microbial membranes by forming pores or micelles. α-Defensins are stored in neutrophil granules and Paneth cells, while β-defensins are produced by epithelial cells. Their broad-spectrum activity constitutes an important chemical barrier of innate immunity at mucosal and epithelial surfaces.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details