Vinclozolin inhibits:
Vinclozolin is fungicide used on fruits and vegetables metabolized in vivo to two active metabolites M1 and M2 capable of competitive androgen receptor antagonism. These metabolites bind androgen receptor ligand-binding domain displacing dihydrotestosterone, preventing receptor dimerization, nuclear translocation and activation of androgen-responsive genes necessary for Wolffian duct maintenance, prostate development and external genitalia masculinization. Male rats exposed gestationally develop shortened anogenital distance, retained nipples, cryptorchidism and hypospadias. Vinclozolin does n
Ref: Gilbert, Developmental Biology, 12th ed., Chapter 20: Vinclozolin inhibits testosterone receptors.
