Homing introns encode
Mobile or homing introns are self-splicing Group I or Group II introns containing open reading frames encoding homing endonucleases, often belonging to LAGLIDADG or HNH families, and sometimes combined maturase-endonuclease functions. Homing endonuclease introduces site-specific double-strand break in intron-less allele, stimulating homologous recombination repair using intron-containing genome as donor, thereby duplicating intron into new allele. This selfish element drives super-Mendelian inheritance, spreads despite fitness cost, and links splicing to DNA mobility. This refined regulation s
Ref: Watson Molecular Biology of the Gene, 7th ed., Chapter 15, Homing introns encoding homing endonucleases
