We use cookies to improve your experience and understand how Examtube is used. You can accept analytics cookies or continue with essential cookies only.
Privacy policy3 public questions tagged with this topic.
Histone proteins help in the packaging of DNA into chromatin by forming nucleosomes.
Ref: NCERT Class 12 Biology Chapter 5: Molecular Basis of Inheritance DNA Structure Double Helix and Packaging - Nucleosome
Histone proteins help in the packaging of DNA into nucleosomes, making up chromatin.
Ref: NCERT Class 12 Biology Chapter 5: Molecular Basis of Inheritance DNA Structure Double Helix and Packaging - Nucleosome
Biochemical reconstitution and high resolution crystal structures confirm nucleosome core particle comprises exactly eight histone proteins forming disc. Two copies each of canonical H2A, H2B, H3, H4 assemble as octamer shaping 11 nanometer particle. Central kernel forms H3-H4 tetramer via four-helix bundle through H3-H3 interface, while two H2A-H2B dimers dock on sides contacting outer DNA wraps. Six histones would destabilize wrapping, ten or twelve exceed structural capacity supported by stoichiometry measurements. Micrococcal nuclease protection and ultracentrifugation correspond to octamer alone, fundamental compaction unit conserved throughout eukaryotes.
Ref: Luger K. et al., Nature 1997 2.8 Å Structure; Alberts et al., Chapter 4: Nucleosome Eight Histones Octamer
This page is supported by advertisements. An ad blocker is stopping those ads from loading, so we cannot show the rest of the page yet. Pause the blocker for this site, then continue. We will check again automatically.
You can keep using this site after advertisements are allowed to load.
