Skip to content
Login Register

#GPCRs

2 public questions tagged with this topic.

Cell Signaling GPCR Pathways - I

GPCRs characteristically contain how many transmembrane helices?

G-protein-coupled receptors share a conserved topology of seven transmembrane α-helices that form a helical bundle spanning the plasma membrane. The extracellular loops and N-terminus contribute to ligand recognition, while the intracellular loops and C-terminus interact with heterotrimeric G proteins and regulatory proteins such as arrestins and kinases. This architecture is the defining structural hallmark of the GPCR superfamily.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details
Cell Signaling GPCR Pathways - I

GPCRs characteristically have

G-protein-coupled receptors share a conserved topology of seven transmembrane α-helices that form a helical bundle spanning the plasma membrane. The extracellular loops and N-terminus contribute to ligand recognition, while the intracellular loops and C-terminus interact with heterotrimeric G proteins and regulatory proteins such as arrestins and kinases. This architecture is the defining structural hallmark of the GPCR superfamily.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details