Which lysosomal enzyme degrades complex polysaccharides?
Lysosomal lumen houses a consortium of about sixty acid hydrolases tailored to distinct macromolecular classes, all evolutionarily optimized for acidic pH and limited activity at neutral pH to protect cell. Among them, glycosidases or glycoside hydrolases hydrolyze glycosidic linkages in oligosaccharides, N-linked glycoproteins, glycolipids and glycosaminoglycans. Examples include acid alpha-glucosidase removing alpha-1,4 linkages in glycogen, beta-galactosidase cleaving galactose from GM1 ganglioside, alpha-mannosidase, neuraminidase, fucosidase, and hexosaminidases A and B that degrade GM2 g
Ref: Alberts et al., Molecular Biology of the Cell, 7th ed., Chapter 13: Lysosomal Hydrolases – Glycosidases.
