Microspheres were proposed by
Sydney Fox showed that heating dry mixtures of amino acids forms proteinoids, which when dissolved in water assemble into microspheres with double-layered boundaries resembling membranes, capable of budding and selective permeability. This provided alternative to Oparin's coacervates for protobiont organization, emphasizing thermal synthesis in volcanic environments. Microspheres exhibited some enzyme-like activity and could incorporate other molecules. The model supports protein-first scenarios and is credited to Sydney Fox, expanding repertoire of protocell concepts. This concept integrates
Ref: Alberts et al., Molecular Biology of the Cell, 6th ed., Chapter 1: Origin of Life.