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#fibronectin

6 public questions tagged with this topic.

frog development

Depletion of Fibronectin in amphibian embryos leads to:

Gastrulation involution requires dynamic cell-matrix interactions. Fibronectin fibrils assembled on blastocoel roof provide RGD-containing substrate for integrin alpha5beta1 mediated adhesion and migration of involuting marginal zone cells. Fibronectin guides radial intercalation pulling mesoderm inside. Depletion using antisense morpholinos, RGD peptides or antibodies eliminates fibrils, causing mesoderm cells to lose traction, failing to involute over blastopore lip. Blastopore remains open, mesoderm accumulates outside, phenotype described as failed involution without dorsalization or axis duplication, indicating purely mechanical movement defect. This illustrates conserved developmental logic of morphogen gradients patterning embryonic axes through Wnt and BMP antagonism.

Ref: Gilbert, Developmental Biology 12th ed., Chapter 10: ECM fibronectin and gastrulation involution.

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Cell Communication

Which statement is NOT true for fibronectin? (June 2019)

Three polypeptides form fibronectin, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Communication and Cell Adhesion

Major ligand for α5β1 integrin is

Fibronectin, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Communication and ECM

Which ECM protein binds integrins via RGD sequence?

Fibronectin, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Communication and ECM

Fibronectin mainly functions in

Cell migration and adhesion, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Protein

The function of fibronectin is primarily:

Electron transport is the accurate answer because it correctly identifies the biological function or role described in this question. In Protein Structure, understanding the specific functions of molecules, enzymes, or structures is fundamental. Electron transport fulfills this particular biological role through its specific structural properties, biochemical activity, or physiological mechanism. The other options (Oxygen storage, Extracellular matrix binding, and Hydroxylation of xenobiotics) serve different biological functions or are associated with other processes, pathways, or structural roles within the cell or organism.

Ref: Lehninger Principles of Biochemistry, Nelson & Cox, 8th Ed., Ch. 4

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