Heterosis is best expressed in which generation?
Heterosis manifests maximally in F1 because every locus combines divergent favorable alleles from two parental inbreds, achieving maximum heterozygosity and complementation of recessive deleterious mutations restoring pathways. Enzyme complementation, increased growth regulators and efficient partitioning produce superior biomass and yield. Mendelian segregation in F2 reduces proportion of heterozygous loci from 100 percent to 50 percent, generating mixture of homozygous genotypes expressing inbreeding depression and breaking favorable epistatic combinations formed in F1. Consequently phenotyp
Ref: Shull GH 1908 concept heterosis; Falconer Quantitative Genetics F1 vs F2; PubMed breakdown heterosis F2 generation.