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#examples

5 public questions tagged with this topic.

Immunological Applications

Which of the following is an example of therapeutic monoclonal antibody?

Cetuximab chimeric IgG1 mAb 152 kDa murine variable regions grafted human constant domains preserving antigen binding specificity reducing HAMA response versus purely murine. Target EGFR HER1 encoded EGFR 7p11.2 overexpressed colorectal lung HNSCC via amplification autocrine loop. Physiologic ligands EGF TGF-alpha amphiregulin bind ECD III inducing conformational change exposing dimerization arm domain II allowing homo hetero-dimerization HER2 HER3 autophosphorylation tyrosines Tyr1068 Tyr1086 Tyr1173 recruiting adaptors Grb2 Shc activating KRAS GTP exchange GDP GTP triggering BRAF MEK ERK pro

Ref: FDA Erbitux Cetuximab EGFR MOA Label; NEJM Cetuximab Colorectal KRAS Wild-type 2008 Van Cutsem; Janeway EGFR Antibody Therapy ADCC Mechanism.

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Basic Evolution

Exaptation example is:

Bird wing from forelimb reflects key principle in quiz on section a solved pyqs, where evolutionary mechanisms shape genetic variation and adaptation. In this context, Bird wing from forelimb aligns with experimental and theoretical evidence from population genetics, behavioral ecology and molecular phylogeny. Textbooks like Campbell Biology, Futuyma Evolution and Hartl Principles illustrate supporting data. Understanding why Bird wing from forelimb fits helps integrate natural selection, drift and species concepts essential for NEET, CSIR-NET and GATE examinations. This concept integrates gen

Ref: Campbell Biology, Evolution Chapters, Selection Types.

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Acid, Base, pH

Which of the following is an example of a Lewis acid?

Al³⁺ is the scientifically accurate answer to this question. Within the study of Acid, Base, pH, this concept is well-established through extensive research and is documented in standard scientific literature. The specific properties, mechanisms, or characteristics of Al³⁺ directly address what is being asked. Among the other options, NH₃, OH⁻, and CH₄ do not correctly answer this question because they either refer to different concepts, describe properties of other molecules or processes, or represent common misconceptions about this topic.

Ref: Lehninger Principles of Biochemistry, Nelson & Cox, 8th Ed., Ch. 2

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