Dmc1 protein functions in
Dmc1 is meiosis-specific RecA homolog expressed during prophase I together with Rad51. While Rad51 participates broadly in repair, Dmc1 is enriched at meiotic double-strand breaks and preferentially drives interhomolog rather than intersister recombination, ensuring at least one crossover per homolog pair. Dmc1 filaments are more resistant to dissociation and cooperate with auxiliary factors Mei5-Sae3 and Hop2-Mnd1 to stabilize heteroduplex and promote directed homology search toward homologous chromosome. Knockout mice show sterility with normal vegetative growth because Dmc1 dispensable for
Ref: Watson et al., Molecular Biology of the Gene, 7th ed., Chapter 12: Dmc1 Meiosis-Specific Recombinase Role
