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#cyclic AMP

2 public questions tagged with this topic.

Cell Signaling GPCR Pathways - I

Phosphodiesterase terminates GPCR signaling by converting

Cyclic-nucleotide phosphodiesterases hydrolyze cAMP or cGMP to the corresponding inactive 5'-monophosphates, thereby terminating the second-messenger signal. Regulation of phosphodiesterase activity provides an important mechanism for controlling the duration and amplitude of cyclic-nucleotide signaling in cells. These enzymes are important pharmacological targets for modulating cyclic nucleotide levels. Careful

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Signaling GPCR Pathways - I

PKA is activated by binding of

cAMP, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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