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NaBr with H₂SO₄ reacts with 1-propanol ( CH₃CH₂CH₂OH ) to form 1-bromopropane ( CH₃CH₂CH₂Br ).
Ref: NCERT Class 12 Chemistry > Chapter 6: Haloalkanes and Haloarenes > Topic: Polyhalogen Compounds - Chloroform Iodoform DDT Freons
O-phosphoseryl-tRNASec transformed to selenocysteinyl-tRNASec by SepSecS, also called Sec synthase SEPSECS, pyridoxal phosphate-dependent enzyme catalyzing beta-replacement reaction. Active site PLP forms internal aldimine with conserved lysine, transaldimination yields phosphoserine Schiff base, phosphate elimination facilitated by base creates aminoacrylate intermediate attacked by selenophosphate. Selenophosphate H2SePO3- synthesized by SPS2 serves as selenium donor, generating selenocysteine attached to tRNA ready for translation. SepSecS specifically recognizes tRNASec long variable arm, rejecting phosphoseryl-tRNASer, preventing off-target production. This final step completes on-tRNA synthesis of twenty-first amino acid, coupling selenium metabolism to protein synthesis machinery elegantly.
Ref: Alberts et al., Molecular Biology of the Cell, 7th ed., Chapter 6: SepSecS Converts Sep-tRNASec to Sec
