#cholera toxin

A Cell Signaling

Receptor for cholera toxin is:

Cholera toxin catalyzes ADP-ribosylation of Gαs, locking the subunit in its GTP-bound active form by inhibiting GTPase activity. Persistent activation of adenylyl cyclase produces massive elevations of cAMP in intestinal epithelial cells, leading to continuous opening of chloride channels and the characteristic watery diarrhea of cholera. Careful

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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A Cell Signaling

Cholera toxin causes diarrhea by:

Cholera toxin catalyzes ADP-ribosylation of Gαs, locking the subunit in its GTP-bound active form by inhibiting GTPase activity. Persistent activation of adenylyl cyclase produces massive elevations of cAMP in intestinal epithelial cells, leading to continuous opening of chloride channels and the characteristic watery diarrhea of cholera. Careful

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Signaling GPCR Pathways - I

Which bacterial toxin leads to profuse watery diarrhea?

Cholera toxin, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Signaling GPCR Pathways - I

Effect of cholera toxin on Gαs is

Cholera toxin catalyzes ADP-ribosylation of Gαs, locking the subunit in its GTP-bound active form by inhibiting GTPase activity. Persistent activation of adenylyl cyclase produces massive elevations of cAMP in intestinal epithelial cells, leading to continuous opening of chloride channels and the characteristic watery diarrhea of cholera. Careful

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Signaling GPCR Pathways - I

Cholera toxin ADP-ribosylates which G-protein subunit?

Cholera toxin catalyzes ADP-ribosylation of Gαs, locking the subunit in its GTP-bound active form by inhibiting GTPase activity. Persistent activation of adenylyl cyclase produces massive elevations of cAMP in intestinal epithelial cells, leading to continuous opening of chloride channels and the characteristic watery diarrhea of cholera. Careful

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details