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#chemotaxis

2 public questions tagged with this topic.

Sea urchin eggs attract sperm via:

Broadcast spawning sea urchins release gametes freely into seawater where sperm must locate relatively immobile eggs efficiently to ensure reproductive success. Egg jelly coat surrounding oocyte releases species-specific peptides that diffuse forming stable chemical gradient extending millimeters. Spermatozoa sense gradient concentration via receptor guanylate cyclase and CatSper Ca2+ channels, adjusting flagellar waveform asymmetry to bias swimming up gradient, classic chemotaxis analogous to bacterial navigation. Electrical signals, temperature gradients or light cues are not directional guides for marine gametes. This peptide-based chemoattraction substantially increases fertilization probability. Resact and speract peptides exemplify chemical attractants guiding sperm propulsion in open ocean.

Ref: Kaupp et al., Annu Rev Physiol, Chemotaxis in sea urchin sperm; Gilbert Chapter 7: Egg jelly chemotaxis.

Progesterone attracts sperm via:

Gradients of progesterone secreted by cumulus cells surrounding ovulated oocyte attract capacitated sperm via chemotaxis. Cumulus-derived nanomolar to micromolar progesterone is detected by sperm membrane hydrolase ABHD2 that degrades 2-arachidonoylglycerol, relieving inhibition of CatSper calcium channel, producing chemotactic calcium transients steering flagellar bending toward source. Experimental microfluidic assays show accumulation of human sperm toward progesterone sources. This chemical attraction operates at short range close to oocyte, refining navigation after long-range thermotaxis and rheotaxis toward fertilization site, improving encounter rates for successful conception and zygote formation.

Ref: Publicover et al., Nature 2008: Progesterone via ABHD2 and CatSper mediates sperm chemotaxis near cumulus.