Which of the following statements about channel proteins is incorrect?
Channel and carrier proteins represent two mechanistically distinct classes of facilitated transport differing in kinetics and conformational dynamics. Channels form transmembrane aqueous pores where ions flow rapidly without strong binding, reaching ten to hundred million per second, gated by voltage, ligand or mechanical stimuli switching between open and closed states. Their selectivity arises from narrow filters where carbonyl oxygens replace hydration, as in potassium channel TVGYG motif, but they avoid large alternating-access changes; binding is weak and transient. Carrier proteins use
Ref: Lodish et al., Molecular Cell Biology, 8th ed., Chapter 11: Carrier vs Channel Mechanisms.