Skip to content
Login Register

#cell growth

11 public questions tagged with this topic.

Animal Tissue Culture 2

Anchorage-dependent cells require:

Anchorage-dependent cells require physical attachment to solid substratum coated with extracellular matrix proteins such as collagen type I, fibronectin, or laminin to progress through cell cycle. Attachment occurs via transmembrane integrin heterodimers α and β binding to RGD sequences in matrix, clustering into focal adhesions recruiting focal adhesion kinase autophosphorylation at Y397, Src recruitment, and downstream activation of PI3K-Akt survival pathway and Ras-MAPK mitogenic cascade inducing cyclin D1 transcription. Without this signaling, normal cells arrest in G1 and undergo anoikis

Ref: Alberts MBoC 6th Ed Ch.19 Integrin signaling anchorage dependence; Lodish MBoC Ch.24 FAK anoikis and cell survival.

View Details
Cell Division

The G2 phase is characterized by:

G2 phase is second gap phase dedicated to growth, quality surveillance, and accumulation of components required for mitosis. After S phase completes DNA synthesis, cells continue protein synthesis, particularly tubulin alpha/beta heterodimers and gamma-tubulin ring complex proteins for spindle assembly, histone variants H2AZ for chromatin stability, and membrane lipid synthesis for organelle expansion. Centrosomes duplicated during S phase mature in G2 by recruitment of pericentriolar material including pericentrin, Cep192, and Cdk5Rap2, acquiring ability to nucleate large astral microtubule a

Ref: Alberts et al., Molecular Biology of the Cell, 7th ed., Chapter 17, G2 as Preparation for M Phase.

View Details
Cancer

Ability of cancer cells to grow in soft agar indicates

Anchorage independence, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details
Cancer

Normal epithelial cells grown in culture typically show

Monolayer growth, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details
Cancer

Uncontrolled proliferation in cancer primarily reflects loss of balance between

Cell division and differentiation, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details
Cancer

Disorganized but reversible abnormal growth is known as

Dysplasia, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details
Cancer

Increase in cell number with normal organization is termed

Hyperplasia, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details
Cancer

Increase in cell size without increase in cell number is called

Hypertrophy, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details
Cell Signaling ELR Pathways - I

EGF receptor primarily regulates

cell growth and proliferation, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details