What happens if Cdc14 phosphatase is inhibited?
When Cdc14 phosphatase activity compromised, consequence is arrest in late anaphase or telophase despite successful cohesin cleavage and initial chromosome segregation. Cdc14 normally released through FEAR and MEN pathways dephosphorylates key CDK substrates: Cdh1 converting APC/C coactivator to Cdh1 isoform leading to degradation of cyclin B, Plk1 and securin remnants, Swi5 transcription factor enabling synthesis of Sic1 stoichiometric CDK inhibitor, Cdc15 reinforcing feedback, and structural proteins Fin1, Ase1, Ask1 promoting spindle stability reversal. Inhibition via genetic deletion, temp
Ref: Stegmeier & Amon, Phenotype of Cdc14 Loss and Mitotic Exit Block, Annu Rev Genet 2004; NCBI, Consequences of Cdc14 Inhibition.