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#caspase activation

2 public questions tagged with this topic.

Immunology

Inflammasomes formed by some NLRs activate

Cytosolic NOD-like receptors detect microbial products or danger signals and can assemble multiprotein inflammasomes that activate caspase-1. Caspase-1 processes the pro-inflammatory cytokines IL-1β and IL-18 and also cleaves gasdermin D to induce pyroptosis. Inflammasome activation therefore links intracellular sensing to both cytokine release and inflammatory cell death. Careful

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Apoptosis

Pyroptosis requires activation of

Pyroptosis is an inflammatory form of programmed cell death driven by inflammatory caspases, principally caspase-1. These caspases cleave gasdermin D, whose N-terminal fragment forms pores in the plasma membrane. Pore formation leads to cell swelling, lysis and release of the pro-inflammatory cytokines IL-1β and IL-18. Pyroptosis is a key effector mechanism of innate immune defense against intracellular pathogens.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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