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#calcium homeostasis

3 public questions tagged with this topic.

Membrane Transportation

The P-class Ca2+ ATPase helps regulate calcium homeostasis by:

Calcium serves as ubiquitous intracellular second messenger regulating muscle contraction, neurotransmitter release, gene expression and apoptosis, requiring precise spatial temporal control. Resting cytosolic free calcium around 100 nanomolar maintained far below extracellular 1 to 2 millimolar and endoplasmic reticulum lumen 400 to 700 micromolar, creating 10,000 fold chemical gradient plus electrical component because membrane potential negative. P-type Ca2+ ATPases accomplish low cytosolic level by active extrusion. Plasma membrane Ca2+ ATPase PMCA ejects calcium outward, while SERCA pumps

Ref: Carafoli, Calcium Pump Review, P-Type Ca2+ ATPases Maintaining Cytosolic Calcium Homeostasis.

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Cell Signaling GPCR Pathways - I

High cytosolic Ca2+ concentration eventually causes

inhibition of Ca2+ channels, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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