What is the correct order of lineage commitment in hematopoietic differentiation?
Early embryonic hierarchy commences from totipotent zygote capable of forming whole organism including extraembryonic placenta and yolk sac membranes required for implantation. First lineage decision segregates trophectoderm outer epithelium, leaving inner cell mass as pluripotent source of epiblast which later forms three germ layers ectoderm, mesoderm, endoderm through gastrulation. Progressively, definitive hematopoietic stem cells arising in aorta-gonad-mesonephros region become multipotent blood-restricted, while subsequent progenitors such as common myeloid progenitor and later megakaryocyte-erythroid progenitors become increasingly unipotent. This sequential restriction mirrors epigenetic silencing of potency genes.
Ref: Gilbert, Developmental Biology, 12th ed., Chapter 6: Totipotent to Unipotent lineage commitment stepwise restriction.