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#beta subunit

3 public questions tagged with this topic.

Membrane Transportation

What is the main role of the beta subunit in Na+/K+ ATPase?

Beta subunit of sodium potassium ATPase is glycosylated type two membrane protein about 300 residues containing single membrane span near N terminus and large extracellular domain folded into immunoglobulin-like beta sandwich stabilized by three disulfide bonds and multiple N-linked glycosylation sites required for quality control. Although alpha subunit houses all catalytic motifs nucleotide binding N domain, phosphorylation P domain DKTGTLT aspartate, actuator A domain TGES dephosphorylation, and ion binding residues in M4 M5 M6 M8, beta does not hydrolyze ATP nor bind ions nor form phosphoe

Ref: Geering, J Bioenerg Biomembr, Beta Subunit Roles in Assembly Stability and Trafficking of Na+/K+ ATPase.

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Cell Communication and Cell Adhesion

Integrins are composed of which subunits?

α and β, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Communication and ECM

Integrins are composed of

α and β subunits, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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