Plasmid-mediated resistance is most commonly associated with:
Plasmid-mediated antibiotic resistance illustrates extraordinary plasticity of bacterial accessory genome and its clinical impact. Resistance R-plasmids and conjugative plasmids frequently carry multiple gene cassettes encoding distinct resistance mechanisms: beta-lactamases including TEM, SHV, CTX-M that hydrolyze beta-lactam rings, aminoglycoside-modifying enzymes such as acetyltransferases AAC, phosphotransferases APH, nucleotidyltransferases ANT that acetylate, phosphorylate or adenylate aminoglycosides, macrolide efflux pumps encoded by mef genes and target modification via erm methylases
Ref: Madigan et al., Brock Biology of Microorganisms, 16th ed., Chapter 9: Plasmid-Mediated Multidrug Resistance Mechanisms.
