Antennapedia mutation forms:
Antennapedia is archetypal homeotic mutant discovered by Balkaschina. Dominant chromosome inversion places Antennapedia gene under eye-antennal enhancers causing ectopic expression in antennal disc. Antennapedia protein promotes thoracic leg programs including expression of homothorax and represses antennal determinants like Distal-less. Resultant antenna-to-leg transformation yields mesothoracic legs complete with claws emerging from head socket where antennae normally reside. Phenotype demonstrates selector gene instructive sufficiency: ectopic expression alone redirects imaginal disc fate f
Ref: Gilbert, Developmental Biology, 12th ed., Chapter 20: Antennapedia mutation antenna-to-leg transformation - ectopic Hox expression.
