Which of the following is NOT a feature of amyloid fibrils?
High protease sensitivity is the correct choice because it does not accurately describe or belong to the category addressed in this question. In the context of Protein Folding, the other options (Insolubility, β-Sheet-rich structure, and Congo red binding) are all valid and well-established concepts. High protease sensitivity is either unrelated to the topic, describes a different biological process, or represents a common misconception. Questions framed as 'which is NOT' require students to identify the exception among otherwise correct statements, demanding comprehensive knowledge of the topic rather than recognition of a single fact.
Ref: Lehninger Principles of Biochemistry, Nelson & Cox, 8th Ed., Ch. 4