Which type of bacteria thrive at pH below 5.5?
pH adaptation shapes microbial diversity. Acidophiles thrive at pH below 5.5 often below 3, found acid mine drainage Rio Tinto, volcanic pools, fermented foods yogurt, gastric epithelium. Maintaining cytoplasm near neutrality around pH 6 involves highly impermeable tetraether lipid membranes, active proton extrusion via primary P type ATPases and secondary antiporters, cytoplasmic buffering with basic amino acids arginine, acid chaperones HdeA preventing periplasmic protein aggregation, and DNA repair systems resistant to depurination. Membrane proteins reduced proton channels, periplasm buffering. Acidithiobacillus ferrooxidans oxidizes ferrous iron sulfur at pH2 generating ferric iron. Helicobacter pylori survives stomach via urease producing ammonia alkalinizing periplasm. Neutrophiles optimum 5.5 to 8.5 include most pathogens Escherichia coli, alkaliphiles optimum above 8.5. Recognizing acidophily important for food preservation acidification inhibits neutrophilic spoilage, controlling bioreactor pH, understanding dental caries Streptococcus mutans acid tolerant demineralizes enamel, and biomining where acidophiles leach metals from ores and generate acid mine drainage environmental challenges.
Ref: Prescott's Microbiology, 11th ed., Chapter 7: Acidophiles - Growth below pH 5.5.