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#acetylation

4 public questions tagged with this topic.

Which histone modification recruits bromodomain proteins?

Acetyl-lysine recognition is mediated by evolutionarily conserved bromodomain, an all-alpha bundle of about 110 amino acids forming hydrophobic pocket that accommodates acetylated side chain via hydrogen bond to conserved asparagine. Found in many transcriptional co-activators including p300, SWI/SNF subunits Brg1 and TAF1, bromodomains anchor complexes to hyperacetylated promoters and enhancers, stabilizing pre-initiation complex assembly. Adjacent bromodomains in BET proteins bind multiple acetyl marks cooperatively. Binding is abolished upon deacetylation by HDACs, highlighting reversible r

Ref: Lodish et al., Molecular Cell Biology, 9th ed., Chapter 8: Bromodomain Readers of Histone Acetylation